OxLDL - induced endothelial proliferation via Rho / ROCK / Akt / p 27 kip 1 signaling : opposite 2 effects of oxLDL and cholesterol
نویسندگان
چکیده
4 5 6 7 Chongxu Zhang, Crystal Adamos, Myung-Jin Oh, Jugajyoti Baruah, Manuela A.A. Ayee, 8 Dolly Mehta, Kishore K. Wary, Irena Levitan 9 10 Division of Pulmonary and Critical Care, Department of Medicine and Department of 11 Pharmacology, University of Illinois at Chicago 12 13 14 Running Title: OxLDL and endothelial proliferation 15 16 17 18 19 20 21 Corresponding Author: 22 Irena Levitan 23 Department of Medicine, University of Illinois at Chicago, 24 840 South Wood Street, Chicago, IL 60612-7323 25 Phone: 312-996-0414 26 Email: [email protected] 27 28 29 Articles in PresS. Am J Physiol Cell Physiol (July 12, 2017). doi:10.1152/ajpcell.00249.2016
منابع مشابه
oxLDL induces endothelial cell proliferation via Rho/ROCK/Akt/p27 signaling: opposite effects of oxLDL and cholesterol loading
Zhang C, Adamos C, Oh MJ, Baruah J, Ayee MA, Mehta D, Wary KK, Levitan I. oxLDL induces endothelial cell proliferation via Rho/ROCK/Akt/p27 signaling: opposite effects of oxLDL and cholesterol loading. Am J Physiol Cell Physiol 313: C340 –C351, 2017. First published July 12, 2017; doi:10.1152/ ajpcell.00249.2016.—Oxidized modifications of LDL (oxLDL) play a key role in the development of endoth...
متن کاملoxLDL induces endothelial cell proliferation via Rho/ROCK/Akt/p27kip1 signaling: opposite effects of oxLDL and cholesterol loading.
Oxidized modifications of LDL (oxLDL) play a key role in the development of endothelial dysfunction and atherosclerosis. However, the underlying mechanisms of oxLDL-mediated cellular behavior are not completely understood. Here, we compared the effects of two major types of oxLDL, copper-oxidized LDL (Cu2+-oxLDL) and lipoxygenase-oxidized LDL (LPO-oxLDL), on proliferation of human aortic endoth...
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OBJECTIVE To understand the mechanism by which oxidants are linked to insulin resistance, bovine aortic endothelial cells were exposed to oxidized low-density lipoproteins (oxLDL) or peroxynitrite. METHODS AND RESULTS OxLDL transiently increased phosphorylation of Erk and Akt within 5 minutes, but 60 minutes later, resulted in decreased insulin-induced Akt phosphorylation. OxLDL promoted a 2-...
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Oxidized LDL (OxLDL) induces proliferation in human umbilical vein endothelial cells (HUVEC). The influence of OxLDL on the cyclin-dependent kinase inhibitor p27(Kip1), on the activity of the small GTPase RhoA as a known regulator of p27(Kip1), and on resulting cell proliferation and hypertrophy was studied. HUVEC were stimulated with OxLDL (1 to 50 mug/ml). Proliferation was quantified by (3)H...
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Oxidized low-density lipoprotein (OxLDL) is a risk factor in atherosclerosis and stimulates multiple signaling pathways, including activation of phosphatidylinositol 3-kinase (PI3-K)/Akt and p42/p44 mitogen-activated protein kinase (MAPK), which are involved in mitogenesis of vascular smooth muscle cells (VSMCs). We therefore investigated the relationship between PI3-K/Akt and p42/p44 MAPK acti...
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